A range of other reproductive indications are starting to be explored, notably in polycystic ovary syndrome, the most common endocrinopathy in women.The temporal nature of chromatin structural changes underpinning pathologic transcription are poorly understood. We measured chromatin accessibility and DNA methylation to study the contribution of…[Read more]

This systematized review found important commonalities among clinical trials of PAP published within the past 25 years and revealed key differences among studies in psychotherapy’s incorporation into PAP. Additional research is needed to identify the unique effect of psychotherapy in PAP.

This systematized review found important commonalities…[Read more]

Ewing sarcoma is an aggressive bone cancer of children and young adults defined by the presence of a chromosomal translocation t(11;22)(q24;q12). The encoded protein, EWS/FLI, fuses the amino-terminal domain of EWS to the carboxyl-terminus of FLI. The EWS portion is an intrinsically disordered transcriptional regulatory domain, while the FLI…[Read more]

Subgroup analyses are assessments of treatment effects based on certain patient characteristics out of the total study population and are important for interpretation of pivotal oncology trials. Rhosin However, appropriate use of subgroup analyses results for regulatory decision-making and product labeling is challenging. Typically, drugs approved…[Read more]

Hormonal and bone biomarkers were in normal clinical ranges, even though EA was low. The only interesting significant association was EA being negatively associated with total body BMD (r = -0.360, P =0.005), opposite of expectations. On average our subjects displayed a state of low EA based upon the criterion which has been primarily developed…[Read more]