Designed bioactives represented 83% of detected analytes. Contaminant summary metrics correlated strong-positive (rho (ρ) 0.569-0.719) to multiple watershed-development metrics, only weak-positive to point-source discharges (ρ 0.225-353), and moderate- to strong-negative with multiple instream invertebrate metrics (ρ -0.373 to -0.652). Risk sc…[Read more]

The discrimination index was 0.816 (adjusted C-index) in the developmental cohort and 0.781 (adjusted C-index) in the external validation cohort. Additionally, in both the developmental and validation datasets, age and tumor size were significantly correlated with each other and were independent indicators for survival (P < 0.05).

We…[Read more]

BACKGROUND Refractory hypertension (RfHTN), a phenotype of antihypertensive treatment failure, is defined as uncontrolled automated office BP [AOBP] ≥130/80 mmHg and awake ambulatory BP [ABP] ≥130/80 mmHg on ≥5 antihypertensive medications, including chlorthalidone and a mineralocorticoid receptor antagonist. Previous studies suggest that RfHTN…[Read more]

tion.

EOS serum lactate, duration of surgery and number of packed RBCs units transfused were potential predictors of post-transplant early extubation.

We aimed to assess the feasibility of using supraglottic devices as an alternative to orotracheal intubation for airway management during anesthesia for endovascular treatment of unruptured…[Read more]

GNAQ-knockdown showed down-regulation of tumour growth through mitogen-activated protein kinase (MAPK) signalling in lung cancer cells, but not increased apoptosis. We found that GNAQ-knockdown induced EMT and promoted invasiveness. GNAQ-knockdown cells injected into the bone marrow of murine tibia induced tumour growth and bone-to-lung…[Read more]