@gaugeturn6
active 1 hour, 9 minutes ago
Human catechol O-methyltransferase (COMT) has actually emerged as a model for understanding enzyme-catalyzed methyl transfer from S-adenosylmethionine (AdoMet) to small-molecule catecholate acceptors. Mutation of a single residue (tyrosine 68) behind the methyl-bearing sulfonium of AdoMet was previously demonstrated to impair COMT activity by […] View
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