KCa2.3 expression was significantly reduced in mesenteric resistance arteries in AMPKα2 knockout mice when compared with littermate control mice. Furthermore, in high-fat diet fed mice, 2-week treatment with AICAR restored endothelial KCa2.3 expression in mesenteric resistance arteries with improved endothelial dysfunction. Our results…[Read more]

De novo mutations in the APC gene are responsible for 20-30% of FAP cases. In the presence of the characteristic RPE lesions, it is important to send the patient for work up of FAP even in the absence of family history of FAP.

The interest in the use of beta-hydroxy-beta-methylbutyrate (HMB) as an intervention to prevent and treat sarcopenia…[Read more]

865) and its three subscale scores (ICC = 0.709-0.882). The constipated participants could be effectively differentiated from the controls based on the CSI total score and its three subscales. The convergent validation was good between the CSI and CSS (Spearman’s ρ = 0.711, p < 0.001). The CSI score correlated negatively with the physical…[Read more]

Malnutrition is highly prevalent in patients with foregut tumors comprising head and neck (HNC) and esophageal (EC) cancers, negatively impacting outcomes. International evidence-based guidelines (EBGs) for nutrition care exist; however, translation of research evidence into practice commonly presents considerable challenges and consequently lags.…[Read more]