This high and rather narrow interval corresponds to the diagnostic specificity seen for many commercial ACPA tests, and represents a specificity that is higher than what is customary for most RF assays. Data on antibody occurrence harmonized in this way should be accompanied by test result-specific likelihood ratios for the target diagnosis RA on…[Read more]

Inhibition of soluble epoxide hydrolase (sEH) has recently emerged as a new approach to treat cardiovascular disease and respiratory disease. Inhibitors based on 1,3,5-triazine chemotype were discovered through affinity selection against two triazine-based DNA-encoded libraries. The structure and activity relationship study led to the expansion of…[Read more]

Although atrial fibrillation (AF) Arrhythmia is highly prevalent within a wide range of populations with major associated risks and due to its episodic occurrence, its recognition remains a challenge for doctors. This paper aims to present and experimentally validate a new efficient approach for the detection and classification of this cardiac…[Read more]

01). The glycaemic response to the mid-morning intervention drink (0-30min) was attenuated following RD supplementation (P < 0.01). Whilst not a primary endpoint we also observed lower systolic blood pressure at day 14 (P = 0.035) and 28 (P = 0.030), compared to day 1, following RD supplementation in the normal weight group. Energy intake and…[Read more]