6%) were regarded as novel potentially predictive mutations. Of the nine functionally validated novel mutations, EGFR Y1069C and ERBB2 E936K were transforming in Ba/F3 cells and demonstrated enhanced signaling activity. Mechanistically, the EGFR Y1069C mutation disrupted the binding of the ubiquitin ligase c-CBL to EGFR, whereas the ERBB2 E936K…[Read more]

es ROS via l’activation de la triade enzymatique anti-oxydante superoxyde dismutase (SOD)/catalase (CAT)/glutathion peroxydase (GPx) et via la régulation à la hausse du GSH prévenant ainsi la lipopéroxydation. La RLN a par ailleurs diminué les atteintes histopathologiques testiculaires préservant la spermatogenèse. En parallèle, la RLN a amélioré…[Read more]

Muscle-metal (As, Se, Hg, Sn, Cr, Ni) levels were measured in little tunny (Euthynnus alletteratus) from the western Algerian stock. Relationships between metal levels in the muscle tissues and fish fork length and total weight were examined. The accumulation of metals in muscle tissues varied in the following ascending order Ni, Cr, Sn, Hg, Se,…[Read more]

To develop a clinical technique for objective estimation of exact location and degree of participation of face and neck soft tissues in age-related deformations for determine effective mini-invasive treatment techniques.

Ultrasound examination was performed in 2017-2019 at 63 patients with age-related face changes. Examination was done in…[Read more]

The microcirculation comprising of arterioles, capillaries and post-capillary venules is the terminal vascular network of the systemic circulation. Microvascular homeostasis, comprising of a balance between vasoconstriction, vasodilation and endothelial permeability in healthy states, regulates tissue perfusion. In severe infections, systemic…[Read more]