9.The global COVID-19 pandemic resulted in restriction of non-essential travel across the globe, as seen in the Office of the Under Secretary of Defense Memorandum, “Force Health Protection Guidance (Supplement 4) DoD Guidance for Personnel Traveling During the Novel Coronavirus Outbreak” (11 March 2020). This resulted in the suspension of most,…[Read more]

Nearly a third of dengue serology-positive cases and a fifth of JE serology-positive cases were co-positive for CHIKV.

Archival data from 2006-2011 and data from this study (2012-2017) indicated that UP experienced first CHIK outbreak in the decade in 2016, as part of a large-scale upsurge across northern India. CHIK should be considered…[Read more]

Using a Holliday-junction-like scrambling mechanism, also analogous to DNA, rings may be manipulated (increased, decreased, exchanged) easily with little to no need for additional energy, the reaction being essentially an isomerization.A literature review is presented describing findings that support the above hypothesis. Reviewed is condensed…[Read more]

Angioedema and urticaria affect people of all ages. Accurate diagnosis and optimum management is essential for healthy aging. Older people continue to experience mast cell-mediated urticaria and angioedema, with a higher prevalence of autoimmune and a lower prevalence of autoallergic disease. Bradykinin-mediated angioedemas are more common in the…[Read more]

RESULTS Doxorubicin significantly upregulated miR-375 expression in vitro and in vivo, and inhibition of miR-375 re-established myocardial redox homeostasis, prevented doxorubicin-induced oxidative stress and cardiomyocyte apoptosis, and activated the PDK1/AKT axis by reducing the direct binding of miR-375 to 3′ UTR of the PDK1 gene. Inhibition of…[Read more]