t of dental caries. Well-conducted studies should be encouraged, measuring mainly the antimicrobial effects of ozone therapy at long term and following the recommendations of the CONSORT statement for the reporting of RCTs.

Optimal force magnitude for bodily orthodontic tooth movement with fixed appliances A systematic review. Theodorou CI, Kuijpers-Jagtman AM, Bronkhorst EM, Wagener FADTG. Am J Orthod Dentofacial Orthop. 2019;156(5)582-592.

No funding involved.

Systematic review.

Systematic review.

Improving oral health of low-income and uninsured young children remains challenging because of reluctance of general dentists to care for very young children or participate in Medicaid, limited involvement of primary care providers in children’s oral health, and lack of parental awareness of the importance of early oral health care. These barriers can be addressed in health centers (HCs) that are the premier sources of primary care for low-income and uninsured populations and a significant Medicaid provider. Many HCs provide dental services on-site, but literature indicates that medical and dental services often remain siloed with limited interaction among providers in addressing the oral health needs of young patients including risk assessment, education, and caries prevention. Accordingly, we developed a conceptual framework and measuring tool for medical dental integration and sought to examine utility of this tool in a purposive sample of HCs.

We developed a conceptual framework for integrated oral high levels of integration could be achieved despite structure and process limitations and sustainable integration depends on leadership and provider commitment and embedding of best practices in daily operations. Further research can illustrate the reliability of our tool and the impact of integration on access.

We found that high levels of integration could be achieved despite structure and process limitations and sustainable integration depends on leadership and provider commitment and embedding of best practices in daily operations. Further research can illustrate the reliability of our tool and the impact of integration on access.

Fluoride Varnish and Dental Caries in Preschoolers A Systematic Review and Meta-Analysis. de Sousa FSO, Dos Santos APP, Nadanovsky P, Hujoel P, Cunha-Cruz J, de Oliveira BH. Caries Res. 2019;53(5)502-513.

Government.

Systematic review with meta-analysis of data.

Systematic review with meta-analysis of data.

Clinical Outcomes Following Immediate Loading of Single-Tooth Implants in the Esthetic Zone A Systematic Review and Meta-Analysis. Cheng Q, Su YY, Wang X, Chen S. click here Int J Oral Maxillofac Implants. 2020;35(1)167-177.

National Natural Science Foundation of China (grant no. 81570999).

Systematic review and meta-analysis.

Systematic review and meta-analysis.

Estimation of the asymptomatic ratio of novel coronavirus infections (COVID-19). Nishiura H, Kobayashi T, Miyama T, etal.Int J Infect Dis 2020;94154-155. https//doi.org/10.1016/j.ijid.2020.03.020.

Self-funded.

Cross-sectional population study.

Cross-sectional population study.

To estimate the association of human papillomavirus (HPV) infection with oral lichen planus (OLP) and oral leukoplakia (OLK), and determine risk cofactors.

Seven databases were searched for case-control or cross-sectional studies of OLP and OLK with healthy controls, published between 1976 and 2020. The Meta package of R software was applied to calculate the pooled odds ratios (OR) and 95% confidence interval (CI).

Thirty-six articles were finally included. OLP and OLK cases had a higher association with HPV infection than controls (OLP OR 4.91, 95% CI 2.76-8.72; OLK OR 2.51, 95% CI 1.55-4.07). In subgroup analyses, the OR of HPV infection was higher with erosive lesions than with nonerosive lesions (OLP OR 5.36 and 3.47, respectively; OLK OR 3.34 and 3.21, respectively). Oral lesions were more strongly associated with HPV16/18 than with HPV6/11 (OLP OR 7.84 and 1.42, respectively; OLK OR 6.05 and 1.87, respectively) and varied by geographic region (OLP OR 4.01-7.02; OLK OR 1.46-27.13).

Oral HPV infection, particularly infection with HPV 16/18, was strongly associated with OLP and OLK. Risk cofactors included erosive lesions and geographic region.

Oral HPV infection, particularly infection with HPV 16/18, was strongly associated with OLP and OLK. Risk cofactors included erosive lesions and geographic region.

Effects of oral supplementation in the management of oral mucositis in cancer patients A meta-analysis of randomized clinical trials. de Menêses AG, Normando AGC, Porto de Toledo I, Reis PED, Guerra ENS. J Oral Pathol Med. 2020;49(2)117-125.

Information not available from the study.

Systematic review with meta-analysis of data.

Systematic review with meta-analysis of data.

The association between smoking and periapical periodontitis a systematic review. Aminoshariae A, Kulild J, Gutmann J.Clin Oral Investig 2020;24(2)533-545. https//doi.org/10.1007/s00784-019-03094-6.

None. The authors declared no conflict of interest.

Systematic review with meta-analysis.

Systematic review with meta-analysis.

The aim of this meta-analysis was to systematically evaluate the efficacy of lycopene in improving maximum mouth opening and other clinical symptoms in patients with oral submucous fibrosis (OSF).

We searched 5 databases PubMed, Web of Science, Embase, The Cochrane Library, and EBSCO. Randomized controlled trials were collected to evaluate the efficacy of lycopene in the treatment of OSF. Each database was searched from inception to April 30, 2019. The RevMan 5.3 software was used for this meta-analysis.

The included studies were 7 randomized controlled trials involving 758 patients with OSF. The results of this meta-analysis showed that lycopene was significantly more effective in improving maximum mouth opening in OSF patients than placebo treatment (mean difference [MD] 3.15; 95% confidence interval [CI] 2.19-4.10, P<.0001, I

= 0%). Compared with control groups, lycopene could significantly increase the maximum mouth opening in patients with OSF after 1month of treatment (MD, 2.40; 95% CI, 2.22-2.