Finally, the utility of the MTIR in organizing research in resilience and advancing theory-testing and development is discussed.Background The risk of malignancy (RoM) of indeterminate thyroid nodules (ITNs) shows a high variability in interinstitutional cohorts. The RoM is partially associated with the cytological degree of atypia and the ultrasound (US) pattern. This study evaluated the cancer risk of ITNs by jointly considering the cytological subcategory and the American Thyroid Association (ATA)-based US risk classification. Methods This study features a retrospective cohort from two Brazilian centers comprising 238 ITNs with confirmed outcomes. US classification, according to ATA-based guidelines, and cytological subcategorization were determined. The cytological subgroups were as follows (1) nuclear atypia (NA) related to papillary thyroid carcinoma (PTC) but insufficient to categorize the cytology as suspicious for malignancy; (2) architectural atypia without NA (AA); (3) both architectural and nuclear atypia (ANA); (4) oncocytic pattern (OP) without NA; and (5) NA not related to PTC (NANP). NA was divided into three subgroups ITNs can reach almost 80% when both NA and ATA-based high-risk US features are present. The presence of such cytological features also increased the RoM in the ATA-based intermediate-risk US category. In addition, AA and OP were not independently related to higher cancer risk. These results strengthen the recommendations for combing cytological subcategorization and US risk classification in the workup for ITNs before the decision of a molecular testing, clinical observation, or diagnostic surgery.Background Similar to poorly differentiated thyroid carcinoma (PDTC), papillary thyroid carcinoma with high-grade features (PTC HGF) demonstrates increased mitotic activity and/or necrosis; however, PTC HGF is excluded from the World Health Organization (WHO) definition of PDTC based on maintained nuclear features of PTC. Methods Consecutive tumors that met criteria for PTC HGF, defined as tumors with maintained nuclear features of PTC and mitoses numbering 5 or more per 10 contiguous high-power fields and/or tumor necrosis, and PDTC (defined as per the WHO criteria) were identified. Clinicopathologic characteristics, follow-up data, and targeted next-generation sequencing results were compared between groups. Results There were 15 PTC HGF and 47 PDTC. PTC HGF was associated with a higher rate of pT4 disease (53% vs. 13%, p = 0.0027) and lymph node metastases (73% vs. 38%, p = 0.049). The disease-specific survival was worse for patients with PTC HGF compared with those with PDTC using Kaplan-Meier estimation (p  less then  0.001) and was worse in subgroup analysis evaluating patients with widely invasive PDTC (i.e., those with a similar rate of pT4 disease) and PTC HGF (p = 0.040). PTC HGF had a higher BRAF V600E mutation rate (42% vs. 3%; p = 0.003), a trend toward more gene fusions (25% vs. 3%; p = 0.052), and a higher rate of relative gain of 1q (67% vs. 15%; p = 0.002) than PDTC. Conclusions Our results demonstrate that PTC HGF are important to recognize based on their aggressive behavior. The molecular differences between PTC HGF and PDTC suggest that PTC HGF should be considered a distinct group from PDTC.This research investigated cases of femicide in Great Britain where perpetrators claimed that victims died in “sex games gone wrong.” Forty-three femicides that resulted in a conviction for murder, manslaughter, or culpable homicide were examined in relation to victim-perpetrator sociodemographic characteristics, victim-perpetrator relationship, homicide details, and criminal justice outcomes. Key patterns within the data were identified. The research highlights that the “sex game gone wrong” narrative has gained traction against a cultural backdrop of normalized bondage, domination, and sadomasochism (BDSM) within neoliberal political economy.Comprehension of speech masked by background sound requires increased cognitive processing, which makes listening effortful. Research in hearing has focused on such challenging listening experiences, in part because they are thought to contribute to social withdrawal in people with hearing impairment. Research has focused less on positive listening experiences, such as enjoyment, despite their potential importance in motivating effortful listening. Moreover, the artificial speech materials-such as disconnected, brief sentences-commonly used to investigate speech intelligibility and listening effort may be ill-suited to capture positive experiences when listening is challenging. Here, we investigate how listening to naturalistic spoken stories under acoustic challenges influences the quality of listening experiences. We assess absorption (the feeling of being immersed/engaged in a story), enjoyment, and listening effort and show that (a) story absorption and enjoyment are only minimally affected by moderate speech masking although listening effort increases, (b) thematic knowledge increases absorption and enjoyment and reduces listening effort when listening to a story presented in multitalker babble, and (c) absorption and enjoyment increase and effort decreases over time as individuals listen to several stories successively in multitalker babble. Our research indicates that naturalistic, spoken stories can reveal several concurrent listening experiences and that expertise in a topic can increase engagement and reduce effort. Our work also demonstrates that, although listening effort may increase with speech masking, listeners may still find the experience both absorbing and enjoyable.In the U.S., cigarette smoking is increasingly concentrated in disadvantaged and vulnerable populations, such as populations with lower income and with mental health needs. Food insecurity is linked with psychological distress and is an independent risk factor for smoking. We prospectively examined how cigarette smoking, food insecurity, and psychological distress operate as risk factors for one another in a 2-year longitudinal analysis of U.S. adults from the 2015 and 2017 Panel Study of Income Dynamics, a nationally representative household survey (N = 7946). this website Using cross-lagged panel analysis, cross-lagged regression coefficients were estimated simultaneously with direct-effect paths, controlling for covariates. Results showed significant bidirectional associations between smoking and food insecurity 2015 smoking predicted 2017 food insecurity, and 2015 food insecurity predicted 2017 smoking. Food insecurity and psychological distress also had significant bidirectional associations. However, the association between smoking and psychological distress was unidirectional 2015 psychological distress predicted 2017 smoking, but not vice versa.