Self-treatment with antibiotics involves obtaining medicines without a prescription, sharing medicines with members of one’s social circle, or using leftover medicines stored at home.

Assess the prevalence, knowledge level, reasons for practicing self-treatment of antibiotic among undergraduate university students.

The study was conducted cross-sectional on a sample of 201 students. A pre-validated questionnaire called “self-treatment with antibiotics”, containing 27 close-ended questions, was administered to each subject. Data were analyzed using SPSS version 16 and the results expressed as counts and percentages.

Knowledge about self-treatment with antibiotics was good in general, and health-related students had a better level of knowledge about self-treatment with antibiotics than non-health-related students. The majority of the participants had not used self-treatment with antibiotics. Gender, age, and the last time antibiotic taken affected selftreatment with antibiotics. The most common indication for self-treatment with antibiotics was flu, cold and tonsillitis. The most common reason for practicing self-treatment with antibiotics was being considered as a convenient and rapid solution. Internet was the main source for university students regarding knowledge about antibiotic use and resistance.

Self-treatment with antibiotics is affected by several social and demographic variables, and the role of media, public policies, university curricula as well as physicians and pharmacists should be enforced and activated to eliminate inappropriate uses of antibiotics and to correct misconceptions that encourage self-treatment with antibiotics.

Self-treatment with antibiotics is affected by several social and demographic variables, and the role of media, public policies, university curricula as well as physicians and pharmacists should be enforced and activated to eliminate inappropriate uses of antibiotics and to correct misconceptions that encourage self-treatment with antibiotics.

To develop cocrytsal of telmisartan for enhancing its solubility in water.

Intermolecular interaction happens in crystal packing; it utilizes and helps us to understand the design of new solid with their respective chemical and physical properties called that crystal engineering. It is a blueprint of molecular solids with specific chemical and physical properties through an understanding and handling of intermolecular interaction for increasing solubility if poor water-soluble drugs.

The study was taken under consideration with an aim to generate and synthesize a cocrystal form of telmisartan (TEL) with L-lysine to improve its water solubility, dissolution, and micrometric properties.

A dry grinding technique, solvent evaporation & cooling crystallization, the results revealed a generation of cocrystals with enhanced solubility by liquid drop grinding method. Hence, this process was further explored to investigate various formulation and process parameters that could significantly affect the crystal solubility, dissolution, and micrometric properties.

The solubility of TEL cocrystals was enhanced by L-lysine. Further, the optimized batch was subjected to its micrometric evaluation & physiochemical characterization like FT-IR, NMR, PXRD. The result of the micrometric evaluation showed better results as compared to standards. The dissolution studies also showed a better dissolution rate for TEL cocrystal tablets than TEL tablets formulation.

Cocrystals of TEL with L-lysine showed better solubility and dissolution rate.

Cocrystals of TEL with L-lysine showed better solubility and dissolution rate.

The aim of the study was to formulate, characterize, and evaluate the resveratrol-loaded cubosomes (RC) through topical application.

Resveratrol (RV) is a nutraceutical compound that has exciting pharmacological potential in different diseases including cancers. Many studies of resveratrol have been reported for anti-melanoma activity. Due to its low bioavailability, the activities of resveratrol are strongly limited. Hence, an approach with nanotechnology has been done to increase its activity through transdermal drug delivery.

To formulate, characterize, and evaluate the resveratrol-loaded cubosomes (RC). To evaluate resveratrol-loaded cubosomal gel (RC-Gel) for its topical application.

RC was formulated by homogenization technique and optimized using a 2-factor 3-level factorial design. Formulated RCs were characterized for particle size, zeta potential, and entrapment efficiency. Optimized RC was evaluated for in vitro release and stability study. Selleckchem Linsitinib Optimized RC was further formulated into cubosomalent simply through topical application.Prostate cancer (PC) is known as the most frequent cancer among men in the world. Androgen Deprivation Therapy (ADT) is one of the initial treatment approaches in the PC therapy and various drugs can be used in routine Hormonal therapy for PC therapy. Nevertheless, PC cells can survive and continue their growth via different mechanisms which lead to their resistance to common treatments i.e., Enzalutamide. Darolutamide (ODM-201) is a second-generation androgen receptor (AR) inhibitor with a new chemical structure and has a high affinity to the AR. Darolutamide doesn’t cross the bloodbrain barrier, for this reason, reduces the possibility of seizures. Darolutamide also can inhibit the transcriptional activity of several AR mutant variants (F877L, F877L/T878A, and H875Y/T878A) which are Enzalutamide resistant. In this review we reviewed the results of different studies in vitro, animal model and phase 1, 2 and 3 clinical trials (ARADES, ARAFOR and ARAMIS). We shall discuss worldwide phase 2 and 3 clinical trials (ARASENS and ODENZA) that are in progress, in order to demonstrate the advantages of Darolutamide consumption in different groups of patients. Darolutamide has shown high potential in inhibiting the growth of MR49F (Enzalutamide resistant PC cells) and VCaP (Castration-resistant PC cells) cell lines and transcriptional activities of AR. Fewer doses of Darolutamide is needed compared to Enzalutamide. The drug had significant anti-tumor activity and had no effect on serum testosterone levels in animal models. Darolutamide demonstrates its safety and efficacy in different studies and was well tolerated nearly in all of the patients.