36±0.15-fold) and Acan (0.41±0.28-fold). Early PTOA synovium rescued the suppression of Acan, induced increased sGAG secretion (3.94±0.44μg/mL vs surgery-naïve 2.41±0.55 and sham 2.92±0.73μg/mL controls), and upregulated Mmp3 (3.73±2.62-fold) and Prg4 (4.93±4.29-fold). These effects were lost with later stage PTOA synovium.

Early PTOA syno…[Read more]