Total harmonic distortion (THD) plays an important role in the performance of miniature loudspeakers used in mobile phones. Traditional nonlinear models fail to predict THD in the higher frequency domain. Significant discrepancies can be found between the prediction and measurement. In this study, an extended model considering nonlinear acoustic…[Read more]

Morphine is a widely used opioid analgesic, which shows large differences in clinical response in children, even when aiming for equivalent plasma drug concentrations. Age-dependent brain disposition of morphine could contribute to this variability, as developmental increase in blood-brain barrier (BBB) P-glycoprotein (Pgp) expression has been…[Read more]