Using a large-scale reference resource, we show that the tissue-anchored model provides a transcriptome-based approach to predicting the primary affected tissue of developmental disorders. Using gradient boosted regression trees to model evolutionary rate under a range of model parameters, selected features explain up to 62% of the variation in…[Read more]

CLU1 and CLU2 induced higher heart rate (range 7.1-10.5%, all p < 0.001 for main effect and protocol [Formula see text] set interactions), lower rating of perceived exertion (range - 1.3 to - 3.2 AU, all p [Formula see text] 0.006 for pairwise comparisons) and lower ratings of fatigue (range - 0.15 to - 4AU, all p [Formula see text] 0.012 for p…[Read more]