s.

Very good to excellent quality evidence indicated that the SANE scale demonstrates evidence of a reliable, valid and responsive tool in patients with shoulder related pathologies.

PROSPERO CRD42018117874.

PROSPERO CRD42018117874.This paper argues that diverse disciplines within the human sciences have converged in identifying the conditions that human beings need to thrive and the programs, policies, and practices that are needed to foster well-being. In the interest of promoting this view, we suggest that this convergence might usefully be labeled “The Nurture Consilience.” We review evidence from evolutionary biology, developmental, clinical, and social psychology, as well as public health and prevention science indicating that, for evolutionary reasons, coercive environments promote a “fast” life strategy that favors limited self-regulation, immediate gratification, and early childbearing. However, this trajectory can be prevented through programs, practices, and policies that (a) minimize toxic social and biological conditions, (b) limit opportunities and influences for problem behavior, (c) richly reinforce prosocial behavior, and (d) promote psychological flexibility. The recognition of these facts has prompted research on the adoption, implementation, and maintenance of evidence-based interventions. To fully realize the fruits of this consilience, it is necessary to reform every sector of society. We review evidence that free-market advocacy has promoted the view that if individuals simply pursue their own economic well-being it will benefit everyone, and trace how that view led business, health care, education, criminal justice, and government to adopt practices that have benefited a small segment of the population but harmed the majority. We argue that the first step in reforming each sector of society would be to promote the value of ensuring everyone’s well-being. The second step will be to create contingencies that select beneficial practices and minimizes harmful ones.

The purpose of this study was to explore the effect of trimethylamine (TMA)-degrading probiotic agents on trimethylamine oxide (TMAO) and the related lipid metabolism in mice.

Ten lipid-lowering strains were detected with TMA-degradation capacity in vitro. After probiotic intervention for the mice on a high-choline diet, TMA content in cecum and TMA and TMAO in serum was explored, as well as the expression of key gene flavin-containing monooxygenase 3 (FMO3) of the TMA-TMAO metabolism. The expression of genes related to the lipid metabolism was also investigated by real-time polymerase chain reaction and Western blot. this website Finally, the colonization of functional strains in the intestine were examined.

Five of 10 lipid-lowering strains effectively degraded TMA in vitro, and the TMA level in the cecum of mice were reduced after probiotic intervention. TMA level and TMAO in serum were also significantly reduced by the strains (P < 0.05), but not due to the regulation of FMO3. Probiotic agents could improve terosclerosis caused by TMAO. However, FMO3 had not changed in this process, and needs further study.Women need to receive accurate information on the proper use of contraceptive methods (CM). The objective of our analysis was to evaluate the quality of CM counseling in health institutions of the public sector using the Lot Quality Assurance Sampling (LQAS) technique. We specifically analyzed whether health-service providers informed CM users of all the side effects they might experience, as specified under the Mexican health-care regulations. Our results demonstrated that, among the four CM analyzed -the intrauterine device, hormonal injection, condom and subdermal implant- only the users of the subdermal implant received complete information on side effects. Our findings thus indicate that the quality of family planning services in the institutions analyzed is deficient. We recommend that service providers be regularly trained in order to improve their performance and that LQAS methodology be adopted as an effective means of regularly monitoring the quality of health services in Mexico.Groundwater quality in human-influenced coastal landscapes is receiving novel attention. Radionuclides have been recognized as another important monitoring indicator in many developed countries due to the discovery of extremely high level of natural 210Po (up to 10,000 Bq/m3) and radium and radon isotopes. This study aims to evaluate the groundwater quality in the Beibu Bulf-Guangxi coast from radiological point of view. 210Po, 210Pb and 222Rn activities in 20 wells ranged from 0.24 ± 0.05 to 6.96 ± 1.62 Bq/m3, 2.17 ± 0.12 to 13.08 ± 0.74 Bq/m3 and 1500 ± 200 to 31,800 ± 900 Bq/m3, respectively. Compared with research data of other countries, groundwaters in this area have 210Po, 210Pb and 222Rn activity within low levels. The large deficiencies of 210Po and 210Pb relative to 222Rn in groundwaters implied that 210Po and 210Pb are strong particle-reactive radionuclides and they might be controlled by similar scavenging processes in groundwaters due to a good positive correlation between 210Pb and 210Po (R2 = 0.67, p less then 0.01). The concentrations of 210Po and 210Pb decreased with increasing pH values and salinity, which indicated that geochemical behaviors of 210Po and 210Pb in groundwater were influenced by seawater intrusion and pH changing. Groundwater 222Rn activity concentrations decreased with increasing salinity in coastal zone, which may be caused by dilution due to seawater intrusion or intensified 222Rn escaping from well-developed pores in coastal zone. The estimated annual ingestion doses for infants, children and adults were well below the recommended reference dose level (RDL) of 0.2-0.8 mSv/a, suggesting that consumption of analyzed groundwaters is safe from radiological point of view.Locally advanced head and neck squamous cell carcinoma (LAHNSCC) treatment consists of radiotherapy (RT) alone or cisplatin-based concomitant chemoradiotherapy (CCRT). CCRT is accompanied by substantially more toxicity than RT alone. A previous retrospective cohort study found that LAHNSCC patients with tumors negative for nuclear expression of the signal transducer and activator of transcription 3 (STAT3) protein might not benefit from the addition of cisplatin to radiotherapy (RT) treatment. We set out to validate these results in a new cohort. We found that in patients with both STAT3 positive and negative tumors, disease-free survival (DFS) and overall survival (OS) did not differ significantly between treatment with cisplatin-based concomitant chemoradiotherapy (CCRT) and radiotherapy alone. Therefore, our validation study does not confirm that STAT3 is a potential biomarker to predict the effectiveness of the addition of cisplatin to RT in LAHNSCC patients.