Objectives Ageist sexual stereotypes may prohibit midlife and older adults from achieving sexual wellness when stereotypical beliefs about aging, sex, and intimacy become internalized over the life course (i.e. stereotype embodiment). Though there are several studies examining the application of stereotype embodiment theory to various health behaviors, it has not been applied to sexual and intimate health across the life course. The current study examined sexual stereotype embodiment by assessing the impact of aging-sexual-stigma on sexual and intimate activity among midlife and older adults.Method In this cross sectional study, a convenience sample of 972 adults aged 50 and older was recruited via a crowdsourcing platform. Participants completed an online survey assessing attitudes about aging sexuality and their participation in a spectrum of sexual and intimate behaviors. Hierarchical linear regression was used to examine the study hypotheses related to sexual and intimate behaviors among middle age and older adults.Results Results of this exploratory study suggest that embodiment of sexual stereotypes effects both midlife and older adults, with endorsement of aging sexual stigma predicting lower engagement in both sexual and intimate activities. Sexual embodiment had similar effects across age cohort and gender.Conclusion In addition to pervasive societal impact, ageist sexual stereotypes appear to affect individual sexual health and wellness via internalized beliefs. This provides preliminary evidence for stereotype embodiment in a novel domain, sexual health. Future research should explore potential age and cohort effects across the life course in longitudinal studies with robust measures of aging sexual stigma.Methods for imaging orthotopic prostate tumors within the prostate or small tumors with extension outside the prostate are needed to more closely model human prostate tumors, which are most commonly located within the gland or may extend just through the gland. By comparing MR sequences, we found that the T2-based Dixon ‘water only’ sequence best visualized tumors within the prostate of mouse models in both young and old mice and that tumor weight derived from this sequence correlated highly with ex vivo tumor weight (r2 = 0.98, p  less then  0.001, n = 12). This should aid tumor detection, margin delineation and evaluation of tumor burden to enable studies including, but not limited to, evaluating the natural history of the disease, the mechanisms of action and the efficacy of therapeutic interventions.Objectives There is an association between affective symptoms and cognition. However, the direction of this association remains unclear. This study aimed to test bidirectional relationships between affective symptoms and cognition from middle to late adulthood.Method Data were available from the MRC National Survey of Health and Development (NSHD), a prospective birth cohort of 5362 people born in 1946. Affective symptoms and cognition were measured at ages 53, 60-64, and 69. Latent scores of affective symptoms were derived and cross-lagged models were fitted for affective symptoms with verbal memory and processing speed. Results Results revealed an inverse cross-sectional association between affective symptoms and verbal memory (β=-0.18, SE=0.04, p less then .001) and processing speed (β=-0.13, SE=0.06, p=.05) at age 53, but not at ages 60-64 or 69. Affective symptoms at age 53 predicted lower verbal memory at age 60-64 (β=-0.58, SE=0.27, p=.03), and affective symptoms at age 60-64 predicted lower verbal memory (β=-0.64, SE=0.29, p=.03) and processing speed (β=-1.27, SE=0.41, p=.002) at age 69. selleck chemicals Verbal memory and processing speed did not predict subsequent affective symptoms.Conclusion Affective symptoms predict poorer verbal memory and processing speed over a period of 16 years, but not vice versa.Background Studies consistently demonstrate that older adults who are lonely have higher rates of depression and increased mortality risk. Pet ownership may be a solution for loneliness; however, challenges related to pet ownership exist for older adults. Therefore, researchers and practitioners are examining the use of animatronic pets to reduce loneliness.Objective To determine the feasibility of an animatronic pet program, and whether ownership of animatronic pets would decrease loneliness and improve well-being among lonely older adults.Methods Eligible individuals were identified as lonely through a prior survey. Participants were provided with the choice of an animatronic pet and completed T1/T2/T3 surveys.Results Attrition was high; 168 (63%) participants completed T1/T2 surveys, and 125 (48%) also completed a T3 survey. Post survey data indicated that loneliness decreased, while mental well-being, resilience, and purpose in life improved. Frequent interactions with the pets were associated with greater improvement in mental well-being and optimism.Conclusions Animatronic pets appear to provide benefits for the well-being of lonely older adults. Future studies should employ randomized controlled designs examining the impact of animatronic pets.Objective To develop a predictive index that estimates the individual risk of incident self-neglect onset among the US Chinese older adults.Methods The study used two waves of longitudinal data from 2713 participants of the Population Study of Chinese Elderly (PINE). Data were collected during 2011-2015 in Chicago, Illinois, with approximately 2-year follow-up intervals. The main outcomes are incident self-neglect cases. Variables in 14 potential predictive domains were considered, which are (1) sociodemographic/socioeconomic, (2) neighborhood/community, (3) immigration and acculturation, (4) adverse events, (5) culture, (6) general wellbeing, (7) health behavior, (8) medical health, (9) health care, (10) physical function, (11) cognitive function, (12) social wellbeing, (13) violence, and (14) psychological wellbeing. Stepwise selection in multivariable logistical regression models and bootstrapping were used to develop and validate the predictive index.Results The 2-year self-neglect incidence rate was 237 (8.