The scapholunate (SLIL) and lunotriquetral interosseous ligament (LTIL) function as the main stabilizers of the proximal carpal row. Even with MR arthrography, component assessability is often limited in orthogonal standard planes due to their horseshoe-like shape and resulting partial volume effects. This study aims to investigate the diagnostic value of reformatting isotropic 3D sequences with respect to the anatomical orientation of the intrinsic carpal ligaments.

In 110 MR arthrograms of the wrist, we investigated the diagnostic accuracy of two radiologists (R1/R2) for SLIL and LTIL injuries in orthogonal standard planes vs. ancillary angulated reformatting of isotropic 3D dual echo steady state sequence. Component assessability and diagnostic confidence were compared between datasets.

The addition of paraxial reformations improved diagnostic accuracy for lesions of the palmar (R1 0.87 vs. 0.93; R2 0.86 vs. 0.93; all p<0.05) and dorsal LTIL (R1 0.85 vs. 0.93; R2 0.82 vs. 0.90; all p<0.05). No significant increase in accuracy could be ascertained for palmar (R1 0.92 vs. 0.94, p=0.50; R2 0.86 vs. 0.92, p=0.07) and dorsal (R1 0.95 vs. 0.95, p=1.00; R2 0.90 vs. 0.94, p=0.29) lesions of the SLIL. Interrater reliability was almost perfect with and without angulated planes for SLIL (κ=0.88 vs. 0.82) and LTIL assessment (κ=0.88 vs. 0.86). For the LTIL, observer confidence and component assessability were superior with anatomical reformations available (all p<0.05).

In contrast to SLIL injuries, diagnosis of LTIL lesions benefits from ancillary paraxial reformations of 3D sequences in MR wrist arthrography.

In contrast to SLIL injuries, diagnosis of LTIL lesions benefits from ancillary paraxial reformations of 3D sequences in MR wrist arthrography.Portal vein thrombosis is a pathological condition characterized by the lumen occlusion of the portal vein and its intrahepatic branches, commonly associated to chronic liver diseases. Portal vein thrombosis is often asymptomatic and discovered as an incidental finding in the follow-up of chronic hepatopathy. Imaging plays a pivotal role in the detection and characterization of portal vein thrombosis in patients with hepatocellular carcinoma. Ultrasound and Color-Doppler ultrasound are usually the first-line imaging modalities for its detection, but they have limits related to operator-experience, patient size, meteorism and the restrained field-of view. Unenhanced cross-sectional imaging doesn’t provide specific signs of portal vein thrombosis except under certain specific circumstances. Conventional contrast-enhanced imaging can depict portal vein thrombosis as an endoluminal filling defect best detected in venous phase and can differentiate between non-neoplastic and neoplastic thrombus based on the contrast enhanced uptake, but not always rule-out the malignant nature. Functional and quantitative imaging techniques and software seem to be more accurate. The purpose of this work is to provide the reader with an accurate overview focused on the main imaging features of portal vein thrombosis.The production of high-affinity antibodies is a key feature of the vertebrate immune system. Antibodies neutralize and clear pathogens, thereby protecting against infectious diseases. However, dysregulated production of antibodies can cause immune pathologies, such as autoimmunity and immune deficiency. Long-lived humoral immunity depends on B-cell help provided by T follicular helper (Tfh) cells, which support the differentiation of antigen (Ag)-specific B cells into memory and plasma cells. Tfh cells are generated from naïve CD4+ T cells following the receipt of inputs from various cell surface receptors, and can undergo further differentiation into subsets with specialised effector functions to induce and maintain serological memory. While genetically modified mice have provided great understanding of the requirements for generating Tfh cells, it is critical that requirements for human Tfh cell generation and function are also established. Key insights into the molecular requirements for human Tfh cells have been elucidated from the systematic analysis of humans with monogenic germline variants that cause inborn errors of immunity characterised by impaired humoral immunity following infection or vaccination or immune dysregulation and autoimmunity. In this review we will discuss how studying rare ‘experiments of nature’ has enabled discovery of non-redundant molecules and pathways necessary for Tfh cell generation, differentiation, regulation and function in humans, and how these findings inform us about basic and clinical immunology.This paper empirically investigates how competition affects physicians’ opportunistic behavior in the context of the utilization of MRI scanners. We examine micro-panel data on Japanese hospitals, where we observe how physicians change their usage of MRI scanners in response to MRI adoption by nearby hospitals. We identify competition-driven physician-induced demand Hospitals lose patients because of MRI adoption by nearby hospitals, and, to compensate for this loss, physicians perform more MRI scans per patient. Although competition may benefit consumers through better access to MRI scanners, it also causes additional physician-induced demand.Cultural evolutionary theory posits that human cultural complexity rests on a set of adaptive learning biases that help to guide functionality and optimality in social learning, but this sits in contrast with the commonly held view that children are unselective “over-imitators.” Here, we tested whether 4- and 6-year-old children use social learning biases flexibly to fine-tune their copying of irrelevant actions. Children watched a video of a majority demonstrating causally irrelevant actions and a minority demonstrating only causally relevant actions. In one condition observers approved of the majority and disapproved of the minority, and in the other condition observers watched the majority and minority neutrally. find more Results showed that both 4- and 6-year-olds copied the inefficient majority more often than the efficient minority when the observers had approved of the majority’s actions, but they copied the efficient minority significantly more when the observers had watched neutrally. We discuss the implications of children’s optimal selectivity in copying and the importance of integrating social approval into majority-biased learning when acquiring norms and conventions and in broader processes of cultural evolution.