gically validated tissue attenuation index enables identification of neointimal foamy macrophages in stented coronary arteries. Such image-based post-processing software algorithm may help discern and triage subjects at increased risk for device-related events.Coinciding with declining rates of marriage and coupled sex in the U.S., some scholars have proposed that the growing availability of “low-cost sexual gratification” or “cheap sex”-sexual activities such as hookups, pornography use, and masturbation that demand little effort or investment-will lead men to find marital commitment less appealing. Using data from two nationally representative surveys of American adults (2012 New Family Structures Study, N = 349; 2014 Relationships in America Survey, N = 1402), the current study tested the thesis that unmarried men’s pornography use, masturbation habits, or frequency of recent hookup sex would be associated with a lower likelihood of them finding marriage desirable. This thesis was unsupported. In both surveys, masturbation and hookup sex were not associated with unmarried men wishing to be married, while pornography use was robustly and linearly associated with a higher likelihood of wanting to be married. GDC-0077 ic50 This association was apparent at both the bivariate level and after taking into account sexual satisfaction, relationship status, beliefs about marriage, and a host of other potential confounds. Findings suggest that, rather than making marriage less desirable, some forms of “low-cost sexual gratification” such as pornography use to predict a comparatively higher desire for marriage. The implications of these findings are considered in light of sex-exchange theories of marital commitment and the large body of previous research connecting pornography use to more liberal, non-monogamous sexual attitudes.

Colorectal carcinoma (CRC) is widely treated by chemotherapy based on an intensely neurotoxic drug oxaliplatin (OXL). We objective to evaluate prospectively the orofacial neurotoxicity during FLOX (fluorouracil + leucovorin + OXL) chemotherapy.

So, 46 patients with CRC were prospectively evaluated during FLOX chemotherapy by 3 cycles (C) of 6weeks (W) each. We weekly applied the orofacial section of the Acute and Chronic Neuropathy Questionnaire of Common Toxicity Criteria for Adverse Events of the National Cancer Institute of the United States of America (Oxaliplatin-specific neurotoxicity scale). Patients were asked the following concerning the severity (scores 0-5) of orofacial symptoms jaw pain, eyelids drooping, throat discomfort, ear pain, tingling in mouth, difficulty with speech, burning or discomfort of the eyes, loss of any vision, feeling shock/pain down back and problems breathing. We summed the scores (0-50) and evaluated the clinicopathological data. Friedman/Dunn, Chi square and multinomial regression logistic tests were used (SPSS 20.0, p < 0.05).

There was a significant increase in sum of orofacial neurotoxicity from baseline to C1.W3, C2.W1 and C3.W5 (p < 0.001) due increase in scores of jaw pain (p < 0.001), eyelids drooping (p = 0.034), throat discomfort (p < 0.001), ear pain (p = 0.034), tingling in mouth (p = 0.015), burning/discomfort of your eyes (p < 0.001), loss of any vision (p < 0.001), feeling shock/pain down back (p < 0.001), problems with breathing (p = 0.045), but not difficulty with speech (p = 0.087). Women (p = 0.021) and young patients (p = 0.027) had significant higher prevalence of orofacial neurotoxicity.

FLOX-related orofacial neurotoxicity begins acutely and remains long term with increased incidence in women and younger patients.

FLOX-related orofacial neurotoxicity begins acutely and remains long term with increased incidence in women and younger patients.

Cancer patients treated with platinum-based chemotherapy can present with ototoxicity symptoms. The purpose of this work is to report the imaging features related to cisplatin ototoxicity.

Between December 2015 and March 2019, a cohort of 96 consecutive patients with lung cancer was selected. Only patients who received cisplatin chemotherapy and underwent an imaging protocol consisting of a Gd-enhanced 3D-BB and 3D-T1W sequence, as well as T2Wsequence to exclude metastases, were included. Labyrinthine enhancement was assessed, and all findings regarding the auditory and vestibular function were retrieved from the clinical files.

Twenty-one patients met the inclusion criteria. The Gd-enhanced 3D-BB images were used to divide them into the labyrinth enhancement group (LEG) and the labyrinth non-enhancement group (LNEG). None of these patients demonstrated enhancing regions on the 3D-T1W images. The labyrinthine fluid remained high on the T2 images in all patients, excluding metastases. The LEG consisted os study demonstrates a correlation between hearing loss and cochlear enhancement and also between vestibular impairment and vestibular/semicircular enhancement on 3D-BB images, which remained invisible on the 3D-T1W images. The labyrinthine enhancement on 3D-BB images in the presence of normal signal intensity of the intralabyrinthine fluid can be used as an imaging biomarker for cisplatin toxicity in daily clinical practice and should not be mistaken for intralabyrinthine metastases.

Arteriovenous fistulas (AVFs) located in the cavernous sinus (CS), clivus, and condyle can be osseous shunts in nature. Here, we reviewed the angioarchitecture, clinical characteristics, and treatment results of AVFs in these lesions.

Twenty-five patients with 27 lesions who underwent rotational angiography in our department between May 2013 and December 2019 were reviewed. We examined 20 CS AVFs, 2 clival AVFs, and 5 condylar AVFs. We divided the anatomical shunted pouches into five locations the dorsum sellae (posteromedial of the CS), posterolateral wall of the CS, lateral wall of the CS, clivus, and condyle. We divided the AVFs into three categories intraosseous, transitional, and nonosseous shunts. We analyzed the characteristics and treatment results.

A total of 33 shunted pouches or points were identified in 27 lesions. The dorsum sellae (n = 16) was the most frequent location. Fourteen AVFs (88%) in the dorsum sellae were osseous (intraosseous or transitional) shunts. All AVFs in the clivus or condyle were also osseous shunts.