A growing body of research has demonstrated how the link between pornography use and various manifestations of psychological distress and dissatisfaction is explained by moral incongruence-the experience of violating one’s deeply held moral values. The predictive power of moral incongruence, however, has yet to be applied to other sexual activities. Drawing on data from available waves of the General Social Surveys (1988-2018 nmen = 6590, nwomen = 7047; 1989-2018 nmen = 3558, nwomen = 4841), this study extended moral incongruence theory by testing whether engaging in same-sex or non-marital sexual activity when one rejects either as morally wrong is associated with a greater likelihood of reporting unhappiness. Analyses demonstrated that American men (but not women) who reported engaging in same-sex sex in the previous year were more likely than other men to say they were unhappy, but only if they viewed homosexuality as “always wrong.” Analyses also showed that American women (not men) who reported higher frequencies of non-marital sex in the previous year were more likely than other women to report being unhappy, but only if they viewed non-marital sex as “always wrong.” Though nuanced by gender, findings affirmed expectations from moral incongruence research Sexual behavior per se is not associated with unhappiness, but moral inconsistency or conflict regarding one’s sexual behavior is.

The cellular origin and molecular mechanisms of Barrett’s esophagus (BE) are still controversial. Trans-differentiation is a mechanism characterized by activation of the intestinal differentiation program and inactivation of the squamous differentiation program.

Renal capsule grafting (RCG) was used to elucidate whether CDX2 overexpression on the basis of P63 deficiency in the esophageal epithelium may generate intestinal metaplasia.

P63

;Villin-Cdx2 embryos were generated by crossing P63

mice with Villin-Cdx2 mice. E18.5 esophagus was xenografted in a renal capsule grafting (RCG) model. At 1, 2, or 4weeks after RCG, the mouse esophagus was immunostained for a proliferation marker (BrdU), squamous transcription factors (SOX2, PAX9), squamous differentiation markers (CK5, CK4, and CK1), intestinal transcription factors (CDX1, HNF1α, HNF4α, GATA4, and GATA6), intestinal columnar epithelial cell markers (A33, CK8), goblet cell marker (MUC2, TFF3), Paneth cell markers (LYZ and SOX9), enteroendocrine celln vivo. Additional factors may be needed to drive this transitional phenotype into full-blown BE.Fat accumulation in the pancreas associated with obesity and the metabolic syndrome (MetS) has been defined as “non-alcoholic fatty pancreas disease” (NAFPD). The aim of this review is to describe the association of NAFPD with obesity, MetS, type 2 diabetes mellitus (T2DM) and atherosclerosis and also increase awareness regarding NAFPD. Various methods are used for the detection and quantification of pancreatic fat accumulation that may play a significant role in the differences that have been observed in the prevalence of NAFPD. Endoscopic ultrasound provides detailed images of the pancreas and its use is expected to increase in the future. Obesity and MetS have been recognized as NAFPD risk factors. NAFPD is strongly associated with non-alcoholic fatty liver disease (NAFLD) and it seems that the presence of both may be related with aggravation of NAFLD. A role of NAFPD in the development of “prediabetes” and T2DM has also been suggested by most human studies. selleck products Accumulation of fat in pancreatic tissue possibly initiates a vicious cycle of beta-cell deterioration and further pancreatic fat accumulation. Additionally, some evidence indicates a correlation between NAFPD and atherosclerotic markers (e.g., carotid intima-media thickness). Weight loss and bariatric surgery decreases pancreatic triglyceride content but pharmacologic treatments for NAFPD have not been evaluated in specifically designed studies. Hence, NAFPD is a marker of local fat accumulation possibly associated with beta-cell function impairment, carbohydrate metabolism disorders and atherosclerosis.

Hemorrhage is a serious complication of endoscopic retrograde cholangiopancreatography (ERCP). However, there is a lack of comparative studies on immediate and delayed hemorrhage. The present study aims to explore the relevant risk factors of immediate and delayed hemorrhage of ERCP and compare the similarities and differences.

ERCP cases conducted by our hospital between January 2017 and January 2020 were selected for retrospective analysis. Then age, gender, basic disease, laboratory examinations, and other relevant clinical information were collected for the analysis.

A total of 1009 ERCP cases were included in the present study. Among these cases, 76 patients were in the immediate hemorrhage group, 28 patients were in the delayed hemorrhage group, and 905 patients were in the non-hemorrhage group. The univariate analysis revealed that choledocholithiasis, pre-cut, and endoscopic papillary sphincterotomy (EST) were risk factors for immediate hemorrhage, while cholangitis, jaundice, coronary heart disease, pre-cut, high postoperative lipase at four hours and amylase at 24h, high postoperative leukocyte, urea, bilirubin, low postoperative platelet counts and fibrinogen, and prolonged prothrombin time (PT) and thrombin time (TT) were risk factors for delayed hemorrhage. The logistic regression analysis revealed that EST, pre-cut, and activated partial thromboplastin time (APTT) were independent risk factors for immediate hemorrhage, while high amylase at 24h after ERCP, high postoperative urea, prolonged TT, and coronary heart disease were independent risk factors for delayed hemorrhage.

Pre-cut was a common risk factor for immediate and delayed hemorrhage, while other risk factors were different.

Pre-cut was a common risk factor for immediate and delayed hemorrhage, while other risk factors were different.

The outbreak of COVID19 evolved rapidly into a global pandemic, forcing hospitals, including inflammatory bowel disease (IBD) referral units, to change their practices to ensure quality of care.

To describe the clinical outcomes and the fulfilment of the treatment schedule of patients with IBD treated with biological agents in a single-center of a red-zone of the pandemic, and to report the patients’ perceptions about COVID-19 and the measures adopted at our center.

Therapeutic adherence and clinical outcomes were collected for all patients undergoing treatment with intravenous biologicals and subcutaneous biologicals at our center. A telephone survey was also performed to assess these patients’ perceptions of the COVID pandemic and the related measures adopted at their IBD unit.

A total of 234 patients were included (117 on intravenous and 117 on subcutaneous biologicals). Only 10% of patients postponed intravenous infusions intentionally and 5% postponed the collection of subcutaneous biologicals at the hospital pharmacy.