On GC cell lines, ELT co-stained with anti-CD44v6 antibody. ELT binding on tumor tissues significantly increased compared with that of paracancer tissues, also showed a linear positive correlation with CD44v6 expression. ELT specifically accumulated in tumor and eliminated in short time

.

ELT can target GC

and

via CD44v6, indicating its potential to serve as a probe for GC targeting diagnosis and therapy.

ELT can target GC in vitro and in vivo via CD44v6, indicating its potential to serve as a probe for GC targeting diagnosis and therapy.

To estimate the causal impact of a change in the national health insurance policy to cover the cost of respiratory syncytial virus (RSV) antigen testing on the incidence of RSV infection by age-groups, we analyzed the sentinel datasets of RSV infection in Japan from 2009-2017.

The causal effect of introducing RSV antigen testing on increasing the reported incidence of RSV infection was quantified using a quasi-experimental difference-in-differences (DID) design and influenza as a control group.

Examining sentinel and virus surveillance datasets, only clinically mild cases have selectively increased from 2012/13. The median estimated incidences of influenza and RSV infection among children aged 0-4 years, the age group that dominates cases of both diseases, were estimated at 5,607 and 1,761 per 100,000 individuals, respectively. Exploring sentinel datasets, only the incidence of RSV infection abruptly increased from 2012/13. Using an age-dependent model, the estimated causal effect on the increase in RSV annual incidence was greatest among children aged 5-9 years, with an estimated additional 1,912 cases per 100,000 individuals (95% CI 418-3,406).

Owing to financial support of bedside RSV antigen testing from 2012/13, the incidence of RSV infection has been elevated. The recent increasing trend in RSV infection incidence should not be directly perceived as an increase in natural infections with RSV.

Owing to financial support of bedside RSV antigen testing from 2012/13, the incidence of RSV infection has been elevated. The recent increasing trend in RSV infection incidence should not be directly perceived as an increase in natural infections with RSV.

Endometriosis is a benign, chronic, gynecological disease which affect the women in reproductive age. The dysfunction of immune system is associated with endometriosis and the diversity of microbiota in genital tract. According to previous studies, microbiota significantly contributes to multi-systemic function, but the evidence of relationship between microbiota and endometriosis remains insufficient.

There are 68 participants were included in this study and 134 samples obtained from the cervical canal, posterior fornix and uterine cavity were analyzed by 16s-rRNA sequencing. The raw data was filtered, analyzed, and visualized, and bio-information methods were used to identify the characteristics of microbiota.

Two different locations near the cervix, cervical canal, and posterior fornix, exhibited no differences in alpha diversity. The microbiota profile of adenomyosis with endometriosis patients is different from control group through PCoA. Among the different disease groups, five microbiotas were diovide a new concept of microbiota/immune system/endometriosis system.

Thyroid disease and thyroid nodules are common clinical problems. Iodine nutrition plays an important role in thyroid disease evolution. Here, we aimed to estimate the iodine nutritional status and prevalence of thyroid disease in the adults of the Heilongjiang Province in northeast China.

We performed a cross-sectional ultrasound (US)-based survey on volunteers aged 20-70 years from 30 regions of the Heilongjiang Province. The participants were recruited using the probability proportional to size (PPS) method, and consent for US screening was obtained from them. The survey was performed by trained technicians using the same US equipment with a 6-15 MHz linear transducer (MyLab 30 cv, Italy) and was hosted in public community locations such as local hospitals and outpatient departments. Information on basic demographic characteristics, such as urinary iodine and iodine intake were collected. The age- and sex-adjusted prevalence of thyroid disease was determined through direct standardization and reported ly prevalent in this age group; however, the intervention rate is low. We provided population-based estimates of the prevalence of thyroid disease and the iodine status in adults of Heilongjiang Province. These findings are useful to support effective intervention planning for thyroid disease.

In Heilongjiang Province, adults aged 20-70 years belong to the optimal iodine status. Further, the salt iodine levels are in the normal range. Thyroid diseases are highly prevalent in this age group; however, the intervention rate is low. We provided population-based estimates of the prevalence of thyroid disease and the iodine status in adults of Heilongjiang Province. These findings are useful to support effective intervention planning for thyroid disease.

To evaluate the association between use of proton pump inhibitor (PPI) and the risk of hospital-acquired acute kidney injury (HA-AKI) in hospitalized children.

We conducted a multicenter retrospective cohort study in hospitalized children aged 1 month to 18 years from 25 tertiary hospitals across China from 2013 to 2015. MK-8776 inhibitor Patient-level data were obtained from the electronic hospitalization databases. AKI was defined and staged using the serum creatinine (SCr) data according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria.

Among 42,232 children analyzed, 11,496 (27.2%) used PPI, 1,760 (4.2%) used histamine 2 receptor antagonist (H2RA), and 3,514 (8.3%) had HA-AKI during hospitalization. Over 85% of PPIs were prescribed for prophylaxis of gastro-duodenal lesions in children. The use of PPI was associated with a significantly increased risk of HA-AKI compared with both non-users [odds ratio (OR), 1.37; 95% confidence interval (CI), 1.23-1.53)] and H2RA users (OR, 1.24; 95% CI, 1.01-1.52). The associations were consistent across children of different age range, gender, subtypes of PPIs and methods of administration. A larger effect was observed in children with chronic kidney disease (OR, 3.37; 95% CI, 2.46-4.62) and those needed intensive care (OR, 1.54; 95% CI, 1.33-1.78). The risk of HA-AKI was increased even within the recommended dosage range of PPI.

PPIs were widely used and associated with an increased risk of HA-AKI in hospitalized children in China.

PPIs were widely used and associated with an increased risk of HA-AKI in hospitalized children in China.