Nanoscale two-dimensional nanostructures have shown great potential as functional components in photocatalysis. Here, investigations on the synthesis of heterostructured hybrids, comprised of 0D CdS nanoparticles as semiconductor and 2D/2D graphene/MoSx as co-catalyst, are reported. The approach involves a rapid microwave-assisted reaction in autoclave conditions, by adopting either a one-step or a two-step protocol. The chemical speciation of the nanocomposites was found to depend strongly on the compounding conditions of the precursor substances. The photocatalytic activity was assessed by monitoring the photodegradation rate of 4-nitrophenol in solution using simulated solar light irradiation. The photocatalytic activity of the hybrids may be attributed to a combination of beneficial characteristics, strongly related to the chemical speciation of the composite components. Moreover, intimate contacts of the latter result in efficient heterojunctions. Overall, the present study provides valuable insight into the development of functional heterostructured photocatalysts comprised of two-dimensional nanomaterials. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.BACKGROUND Eating behaviour in childhood has been implicated in development of early childhood caries. Parenting feeding styles can also contribute to development of various eating behaviours. AIM To evaluate relationship between children’s eating behaviour and parental feeding styles with ECC in preschool children. DESIGN A case-control study was conducted in 440 children who were selected and divided into 2 groups Group A-children with ECC and Group B-children without ECC. Dental caries was recorded using dmft index. The parents of children in both groups were requested to complete the Children’s Eating Behaviour Questionnaire (CEBQ) and Parental Feeding Style Questionnaire (PFQ). RESULTS There was positive association of food avoidance subscales of CEBQ (Satiety Responsiveness, Food Fussiness, Slowness in Eating, and Emotional Undereating) along with certain food-approaching subscales (Desire to Drink and Emotional Overeating) with dental caries status. It was also seen that parental feeding patterns such as Encouragement and Instrumental feeding contributed to decrease in dental caries of the child when compared to Control and Emotional feeding. CONCLUSION Certain eating and feeding behaviours can possibly be associated with development of ECC, such behaviours can be successfully identified using CEBQ and PFQ. © 2020 BSPD, IAPD and John Wiley & Sons A/S. selleckchem Published by John Wiley & Sons Ltd.BACKGROUND To evaluate disease control, toxicities, and dose to dysphagia/aspiration risk structures (DARS) using a direct gross tumor volume (GTV70Gy ) to planning target volume expansion (dPTV70Gy ) for patients with squamous cell carcinoma of the larynx (LSCC). METHODS A retrospective review was performed on patients with LSCC treated between 2003 and 2018. Clinical outcomes, toxicities, and dosimetric data were analyzed. RESULTS Seventy-three patients were identified. Overall survival at 5-years was 57.8%. Five-year local and regional control was 79.8% and 88.2%, respectively. Distant metastatic-only failure was 2.7%. Eighty percent of failures were 95% contained within the dPTV70Gy . Mean dose and the volume of DARS receiving 70 Gy was significantly lower for dPTV70Gy compared to a consensus-defined PTV70Gy . DISCUSSION Judicious reduction in high-dose target volumes can preserve high tumor control rates while reducing dose to normal surrounding structures underscoring the potential benefit of this approach in enabling local therapy intensification to improve locoregional control. © 2020 Wiley Periodicals, Inc.BACKGROUND Associations between body mass index (BMI) and caries have been reported. AIM To evaluate the direction of the relationship between BMI and severe early childhood caries (S-ECC). DESIGN Children were recruited as part of a larger prospective cohort study assessing changes in nutritional status following dental rehabilitation under general anaesthetic. Pre-operative anthropometric measurements were used to calculate BMI z-scores (BMIz). Operative reports were reviewed to calculate caries scores based on treatment rendered. Analysis included descriptive statistics, bivariate analyses, and simple and multiple linear regression. RESULTS Overall, 150 children were recruited with a mean age of 47.7 ± 14.2 (SD) months; 52% female. Over 42% were at risk for overweight, overweight or obese. Although simple linear regression demonstrated a significant positive association between dmfs score and BMIz, adjusted multiple linear regression found no significant relationship between BMIz and dmfs, but highlighted a relationship between BMI z-score and family income, Registered First Nations Status and physical activity. CONCLUSIONS Although a significant relationship between BMI and S-ECC was not found, poverty was a key confounding variable. As both S-ECC and obesity are known predictors of future disease, it is important for healthcare professionals to identify children at risk. Diet and behaviour modification may play a role in disease prevention. © 2020 BSPD, IAPD and John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.BACKGROUND There have been few recent advances in the identification of occult lymph node metastases (OLNM) in oral squamous cell carcinoma (OSCC). This study aimed to develop, compare, and validate several machine learning models to predict OLNM in clinically N0 (cN0) OSCC. METHODS The biomarkers CD31 and PROX1 were combined with relevant histological parameters and evaluated on a training cohort (n = 56) using four different state-of-the-art machine learning models. Next, the optimized models were tested on an external validation cohort (n = 112) of early-stage (T1-2 N0) OSCC. RESULTS The random forest (RF) model gave the best overall performance (area under the curve = 0.89 [95% CI = 0.8, 0.98]) and accuracy (0.88 [95% CI = 0.8, 0.93]) while maintaining a negative predictive value >95%. CONCLUSIONS We provide a new clinical decision algorithm incorporating risk stratification by an RF model that could significantly improve the management of patients with early-stage OSCC. © 2020 Wiley Periodicals, Inc.