ects.

To determine whether medialization of the proximal tibia due to a varus deformity is related to lateralization of the tibial tuberosity in varus knee osteoarthritis (OA).

A total of 120 knees that underwent osteotomies around the knee for varus knee OA were enrolled. Mechanical medial proximal tibial angle (mMPTA) was measured on radiographs. The angle between the mechanical and anatomical axes of the tibia (angle MA) and the distance between the centre of the tibial plateau and the anatomical axis (distance MA) were measured in the coronal plane on computed tomography images. The tibial tuberosity-posterior cruciate ligament (TT-PCL) distance, the distance between the midpoint of the tibial tuberosity and the centre of the tibial plateau (TT-centre distance), and the angle between the line through the midpoint of the tibial tuberosity and the centre of the tibial plateau and the anteroposterior axis (TT-centre angle) were measured in the axial plane. The correlations of these parameters were evaluated.

mMPTA correlated negatively with angle MA (r=-0.37, P<0.01) and distance MA (r=-0.55, P<0.01). Angle MA and distance MA correlated with TT-PCL distance (r=0.39, P<0.01, r=0.42, P<0.01), TT-centre distance (r=0.35, P<0.01, r=0.38, P<0.01) and TT-centre angle (r=0.36, P<0.01, r=0.36, P<0.01).

Medialization of the proximal tibia due to a varus deformity may induce lateralization of the tibial tuberosity.

Medialization of the proximal tibia due to a varus deformity may induce lateralization of the tibial tuberosity.

We aimed to analyze the surface morphology of the distal femur in three dimensions for the healthy elderly, based on the concept that the surgical epicondylar axis (SEA) is a better surrogate for the flexion-extension axis of the knee joint.

We studied 77 healthy elderly volunteers (40 males and 37 females; age, 68±6years). The medial and lateral contact lines were calculated three-dimensionally, using the highest points of the medial and lateral condyles in 201 cross-sectional planes around the SEA (every 1°, -60° (hyperextension) to 140° (flexion)). A piecewise fitting function consisting of two linear segments was applied to detect the inflection point of the constant radii in the sagittal plane. The main assessment parameters were knee flexion angle at the inflection point of the radius (inflection angle), mean radius from 0° to the inflection angle (constant radius), and coronal tilt angle of the contact line.

The inflection angles, constant radii, and coronal tilt angles were 78.2±8.6°, 26.1±2.3mm, and -0.6±3.2° and 65.6±9.2°, 23.9±2.2mm, and 6.2±3.2° in the medial and lateral condyles, respectively (all, P<0.001). The coronal alignment was 88.7±2.2°.

The medial and lateral femoral condyles showed asymmetrical morphologies with the almost ‘constant’ radius of sagittal curvature from 0° to around 80° and 65° of knee flexion, respectively.

The medial and lateral femoral condyles showed asymmetrical morphologies with the almost ‘constant’ radius of sagittal curvature from 0° to around 80° and 65° of knee flexion, respectively.The main corneal infections reported worldwide are caused by bacteria and viruses but, recently, the number of Acanthamoeba keratitis (AK) cases has increased. Acanthamoeba genus is an opportunistic free living protozoa widely distributed in environmental and clinical sources, with two life-cycle stages the trophozoite and the cyst. AK presents as primary symptoms eye redness, epithelial defects, photophobia and intense pain. An early diagnosis and an effective treatment are crucial to avoid blindness or eye removal but, so far, there is no established treatment to this corneal infection. Diverse research studies have reported the efficacy of commercialized eye drops and ophthalmic solutions against the two life cycle stages of Acanthamoeba strains, that usually present preservatives such as Propylene Glycol of Benzalkonium chloride (BAK). These compounds present toxic effects in corneal cells, favouring the inflammatory response in the so sensitive eye tissue. In the present work we have evaluated the efficacy of nine proprietary ophthalmic solutions with and without preservatives (ASDA Dry Eyes Eyedrops, Miren®, ODM5®, Ectodol®, Systane® Complete, Ocudox®, Matrix Ocular®, Alins® and Coqun®) against the two life cycle stages of three Acanthamoeba strains. Our work has demonstrated the high anti-Acanthamoeba activity of Matrix Ocular®, which induces the programmed cell death mechanisms in Acanthamoeba spp. trophozoites. The high efficacy and the absence of ocular toxic effects of Matrix Ocular®, evidences the use of the Arabinogalactan derivatives as a new source of anti-AK compounds.Methanol dried over powdered 4 Å molecular sieves can be used for a selective mono-de-O-acetylation of the phenolic acetyl group of the per-O-acetyl protected brasilicardin A carbohydrate side chain. This reaction opens a practical procedure for a synthetic access to derivates of the immunosuppressive and cytotoxic natural product brasilicardin A.Self-injurious thoughts (SITs) fluctuate considerably from moment to moment. As such, “static” and temporally stable predictors (e.g., demographic variables, prior history) are suboptimal in predicting imminent SITs. This concern is particularly true for “online” cognitive abilities, which are important for understanding SITs, but are typically measured using tests selected for temporal stability. Advances in ambulatory assessments (i.e., real-time assessment in a naturalistic environment) allow for measuring cognition with improved temporal resolution. The present study measured relationships between “state” cognitive performance, measured using an ambulatory-based Trail Making Test, and SITs. Self-reported state hope and social connectedness was also measured. Data were collected using a specially designed mobile application (administered 4x/week up to 28 days) in substance use inpatients (N = 99). Pilaralisib ic50 Consistent with prior literature, state hope and social connectedness was significantly associated with state SITs.