Solid-state transformations in metal-organic frameworks (MOFs) are important and have led to the creation of new MOF structures. Solid-state transformations from interpenetrated to non-interpenetrated networks involving rearrangement of secondary building units (SBUs) in a single-crystal-to-single-crystal (SCSC) fashion have not been explored to date. Herein, we report the sequential, thermally stimulated solid-state transformations in a barium-organic framework (UPC-600). The two-fold interpenetrated framework of UPC-600 is converted at 373 K into UPC-601, a non-interpenetrated framework. This proceeds in a SCSC fashion and involves the rearrangement of two proximate rod-shaped SBUs in different nets to generate a new rod-shaped SBU. At 473 K, a continuous solid-state transformation involving a second rearrangement occurred, UPC-601 converted into UPC-602 by the rearrangement of the 1D rod-shaped SBU to a 2D layer SBU. This is the first example of such a thermally driven stepwise transformation involving simultaneous cleavage and regeneration of multiple bonds.

The cytoprotective PTEN-induced kinase 1 (PINK1)-parkin RBR E3 ubiquitin protein ligase (PRKN) pathway selectively labels damaged mitochondria with phosphorylated ubiquitin (pS65-Ub) for their autophagic removal (mitophagy). Because dysfunctions of mitochondria and degradation pathways are early features of Alzheimer’s disease (AD), mitophagy impairments may contribute to the pathogenesis.

Morphology, levels, and distribution of the mitophagy tag pS65-Ub were evaluated by biochemical analyses combined with tissue and single cell imaging in AD autopsy brain and in transgenic mouse models.

Analyses revealed significant increases of pS65-Ub levels in AD brain, which strongly correlated with granulovacuolar degeneration (GVD) and early phospho-tau deposits, but were independent of amyloid beta pathology. Single cell analyses revealed predominant co-localization of pS65-Ub with mitochondria, GVD bodies, and/or lysosomes depending on the brain region analyzed.

Our study highlights mitophagy alterations in AD that are associated with early tau pathology, and suggests that distinct mitochondrial, autophagic, and/or lysosomal failure may contribute to the selective vulnerability in disease.

Our study highlights mitophagy alterations in AD that are associated with early tau pathology, and suggests that distinct mitochondrial, autophagic, and/or lysosomal failure may contribute to the selective vulnerability in disease.

This work sought to evaluate the correlation between the five domains of the Polycystic Ovary Syndrome Questionnaire (PCOSQ) and anxiety and depression scales and the clinical phenotype and fertility outcomes in infertile polycystic ovary syndrome (PCOS) patients and to determine the effect of quality of life (QOL) on the clinical, biochemical and fertility disorders in these patients.

The data in this study came from a large-scale hospital-based cohort survey of infertile PCOS patients across mainland China. A total of 1000 infertile PCOS subjects diagnosed according to the modified Rotterdam criteria ranging in age from 20 to 40 years in 21 sub-centers (27 hospitals) were enrolled. Baseline anthropometric parameters, endocrine indexes, metabolic panel, QOL questionnaires and the fertility outcomes of ovulation, conception, pregnancy, pregnancy loss and live birth were collected.

PCOSQ scores were significantly correlated with most of the baseline parameters. PCOSQ-weight domain scores of National Institute of Health-PCOS group were significantly lower compared with non-National Institute of Health-PCOS group. The five domains scores of PCOSQ were significantly negatively correlated with the body mass index levels of PCOS patients. The serum testosterone levels (total testosterone, free testosterone and free androgen index) were significantly negatively correlated to the scores for the weight, body hair, infertility and emotion domains of PCOSQ. Scores on the anxiety and depression scales were significantly and positively correlated with luteinizing hormone, luteinizing hormone/follicle-stimulating hormone levels. In the low-score group of infertility domain, the rates of conception, pregnancy and live birth decreased significantly.

QOL appears to have an impact on the physical symptoms of PCOS, and the emotional stress of infertility affects fertility outcomes.

QOL appears to have an impact on the physical symptoms of PCOS, and the emotional stress of infertility affects fertility outcomes.To address the dendrite growth and interface instability of high-capacity Li metal anode, heterogeneous seed-decorated 3D host materials are expected to suppress the growth of Li dendrites. The physical stability and chemical reactivity of these nanoseeds are the decisive conditions for long cycling lithium metal batteries. Apoptosis inhibitor Herein, carbon nanofibers decorated with uniform CrO0.78N0.48 nanoparticles (ACrCFs) are synthesized by a novel in situ growing method, where the size, composition, distribution, and migration behavior of these nanoparticles are controlled by the introduction of asphaltene. As the 3D host materials for Li anodes, ACrCFs exhibit an excellent lithiophilicity, a superior mixed ion-electron conductivity, and abundant electrochemical active sites. Thus, the ACrCF-modified Li anodes deliver a smooth Li morphology, low nucleation overpotential (10.4 mV), superior cyclic stability with 320 stable cycles (Coulombic efficiency, >98.0%) at 1 mA cm-2, and excellent plating/stripping stability over 1000 h. Notably, no obvious detachment or chalking of these nanoparticles occur during the cycling process. The full cell with LiFePO4 cathode also delivers a better rate capability with more stable cycling performance. The homogeneous CrO0.78N0.48 nanoparticles achieved by this in situ growing method also promise a facile method for the potential applications of transition-metal oxynitride for high energy density battery systems.

Varied and limited opportunities to assist during operations, hamper surgical procedural training. Furthermore, the trainee’s view of the procedure differs from that of the operating surgeon. New solutions could emerge when instruction under direct supervision can be combined with technological advances in surgical practice. This study assesses the feasibility of using the GoPro HERO

to record operations for educational purposes, from the perspective of the surgical and technical team.

A “point-of-view” wearable GoPro camera was used to record standard operations at Tygerberg Academic Hospital, affiliated with Stellenbosch University, in Cape Town. Semi-structured interviews evaluated the practical acceptability of the GoPro in theatre by clinical personnel. The technical team reflected on picture quality, video editing and formatting. Techsmith Camtasia Studio 9

programme was employed for post- recording editing.

Eight operations were performed by three surgeons. No interference with operative sterility, procedural length, nor functioning in the operating room was encountered by clinical personnel.