Insulin receptor (IR) was discovered in 1970. Shortcomings in IR transcribed signals were found pro-diabetic, which could also inter-relate obesity and atherosclerosis in a time-dependent manner. Low-density lipoprotein receptor (LDLR) was discovered in 1974. Later studies showed that insulin could modulate LDLR expression and activity. Repression of LDLR transcription in the absence or inactivity of insulin showed a direct cause of atherosclerosis. Leptin receptor (OB-R) was found in 1995 and its resistance became responsible for developing obesity. The three interlinked pathologies namely, diabetes, atherosclerosis, and obesity were later on marked as metabolic syndrome-X (MSX). In 2012, the IR-LDLR inter-association was identified. In 2019, the proficiency of signal transmission from this IR-LDLR receptor complex was reported. LDLR was found to mimic IR-generated signaling path when it remains bound to IR in IR-DLR interlocked state. This was the first time LDLR was found sending messages besides its LDL-clearing activity from blood vessels.

To describe academic nurses’ experiences engaging clinical nurses in utilizing and implementing developmental and research-based knowledge in hospital settings.

This study used a descriptive qualitative design. Fourteen academic nurses at Masters or PhD level from three different regions of Denmark participated in the study, relating their successful experiences engaging clinical nurses in utilizing and implementing developmental and research-based knowledge. Data were collected in February 2020 through qualitative semi-structured interviews and analysed using a qualitative manifest content analysis.

The main theme revealed was that academic nurses were ‘Working towards creating a practice-related culture for research’ to engage clinical nurses. This was supported by three subthemes ‘Focusing on evidence-based practice knowledge’, ‘Facilitating knowledge through a pedagogical approach’ and ‘Aiming for future changes’.

The academic nurses experienced their engagement of clinical nurses and the subsequent change of practice in patient care and nurses’ workflows in the department settings, as successful due to the academic nurses’ pedagogical actions to educate clinical nurses and due to the academic nurses’ practice-related approach to research and implementation.

The academic nurses experienced their engagement of clinical nurses and the subsequent change of practice in patient care and nurses’ workflows in the department settings, as successful due to the academic nurses’ pedagogical actions to educate clinical nurses and due to the academic nurses’ practice-related approach to research and implementation.

Spirometry is a clinically useful test that can be used to assess lung function among children. Different equations had been formulated to determine the spirometric reference values depending on several individual characteristics. However, the widely used equations do not produce perfect suitability for Middle Eastern children.

This study aims to formulate Middle Eastern-specific equations that may be applicable for other populations in the region.

The spirometric data were collected from Jordanian children between the ages of 6 and 17 years. The collected data were used to formulate customised reference equations for Middle Eastern children using generalised additive models for location, scale and shape. The newly formulated equation results were compared with Global Lung Initiative 2012 (GLI-2012) equations predicted values.

Spirometric values for 1576 healthy participants (870 males) were used to formulate the new equations. The assessment of z-scores produced by the present study equations and GLI-2012 indicated that the new equations were more suitable than GLI-2012 for Middle Eastern children. In-depth analysis of the results indicated that the suitability of GLI-2012 equations varied between different age points.

This study formulated new spirometric reference equations for Middle Eastern children that can improve the diagnosis and management of different respiratory conditions.

This study formulated new spirometric reference equations for Middle Eastern children that can improve the diagnosis and management of different respiratory conditions.Rhaponticin is a constituent isolated from numerous medicinal herbs. It has been reported earlier that rhaponticin possesses numerous biological effects like antiallergic, antidiabetic, hepatoprotective, and antithrombosis. The goal of this exploration was to scrutinize the therapeutic potential of rhaponticin on ovariectomy (OVX)-triggered osteoporosis in rats. Female Sprague Dawley rats were arbitrarily allocated to a sham-operated control group I, group II, which underwent OVX, and groups III and IV that underwent OVX were administered with rhaponticin (10 and 20 mg/kg). Rhaponticin was supplemented orally after 4 weeks of OVX and continued for about 16 weeks. Our findings exhibit that rhaponticin prevented the BMD diminution of femurs, induced by OVX, and protected the worsening of trabecular microarchitecture that are assisted through a noteworthy decline in skeletal remodeling as noticed through the diminished status of bone markers in a dose-dependent manner (10 and 20 mg/kg). OVX rats treated with rhaponticin efficiently enhanced body weight, lipid profiles, uterine index, bone turnover markers, inflammatory markers, and augmented the incidence of calcium in the OVX rats. Rhaponticin was established to restrain the functions of acid phosphatase, estradiol, and bone gla protein in OVX rats. Also, rhaponticin displayed some beneficial effects on histomorphometric and histopathological examination. It was observed that tabular area and thickness were reinstated in sham control and rhaponticin-treated OVX rats. We recognized that rhaponticin did not induce a damaging outcome on the skeletal organization of OVX rats. Moreover, we denote that rhaponticin can be an exceptional agent for the treatment and deal with associated bone diseases.

E-cigarette use has become increasingly prevalent, but there is some evidence demonstrating potential harms with frequent use. We aimed to identify the profiles of e-cigarette users from a regional community in Australia and investigate the associations of e-cigarettes with respiratory symptoms and lung function.

A total of 519 participants completed a cross-sectional study. Exposure to e-cigarettes was collected via a validated questionnaire. Respiratory symptoms were evaluated via a self-reported questionnaire and lung function measured with spirometry and forced oscillation technique (FOT). Linear and logistic regression models were fitted to investigate the associations between e-cigarettes and outcomes, while controlling for confounders such as tobacco smoking.

Of the 519 participants, 46 (9%) reported e-cigarette use. Users tended to be younger (mean ±SD 45.2± 14.5 vs. 55.3± 16.0 years in non-users), concurrently using tobacco products (63% vs. Etomoxir 12% in non-users), have a mental health diagnosis (67% vs.