However, the meta-analysis of RCTs did not confirm these findings.

Patient activation can be assessed and addressed uniformly across all chronic conditions to improve patient engagement in care.

Patient activation can be assessed and addressed uniformly across all chronic conditions to improve patient engagement in care.Members of class VII cytochromes P450 are catalytically self-sufficient enzymes containing a phthalate dioxygenase reductase-like domain fused to the P450 catalytic domain. Among these, CYP116B46 is the first enzyme for which the 3D structure of the whole polypeptide chain has been solved, shedding light on the interaction between its domains, which is crucial for catalysis. Most of these enzymes have been isolated from extremophiles or detoxifying bacteria that can carry out regio- and enantioselective oxidation of compounds of biotechnological interest. Protein engineering has generated mutants that can perform challenging organic reactions such as the anti-Markovnikov alkene oxidation. This potential, combined with the detailed 3D structure, forms the basis for further directed evolution studies aimed at widening their biotechnological exploitation.

The accuracy of impressions for implant-supported prostheses is essential to ensure a passive fit of the definitive prosthesis. Intraoral scanners (IOSs) have been developed as an alternative to complete-arch implant-supported restorations; however, whether they are sufficiently accurate when more than 3 nonaligned implants are involved is unclear.

The purpose of this pilot clinical study was to determine whether the fit of complete-arch zirconia implant-supported frameworks processed on a cast obtained with an IOS and adjusted with an auxiliary device is equivalent to a prosthesis obtained from an elastomeric impression.

Twelve consecutive participants who were ready for complete-arch restorations on already osseointegrated implants were enrolled. Two records were made, one open-tray with polyether and splinted impression copings and the second with an IOS. A verification gypsum device was used for the elastomeric impression, and a prefabricated auxiliary device was used to adjust the intraoral scans. Two zirconia frameworks with the same design were processed and evaluated intraorally by 2 independent calibrated observers.

In 11 of the 12 participants, the digitally processed prosthesis was preferred over the conventionally processed prosthesis. The clinical fit of the prostheses obtained with the completely digital workflow was better than that of those obtained with the conventional workflow.

The use of a prefabricated auxiliary device after intraoral scanning allowed delivery of complete-arch implant-supported monolithic zirconia prostheses with a fit better than those fabricated from conventional impressions.

The use of a prefabricated auxiliary device after intraoral scanning allowed delivery of complete-arch implant-supported monolithic zirconia prostheses with a fit better than those fabricated from conventional impressions.

Evidence to validate the routine use of angled screw-channel abutments in the anterior maxilla is sparse. BTK inhibitor If properly planned, they might provide surgical and prosthetic benefits.

The purpose of this observational study was to determine the prevalence of digitally placed implants in the anterior maxilla that would allow screw-retained implant-supported restorations with either a straight or an angled screw-channel abutment.

Two hundred cone beam computed tomography (CBCT) scans met the inclusion criteria for retrospective analysis and digital implant planning. Virtual implants were planned for randomly selected anterior maxillary teeth by using the anatomic crown and root position. Virtual abutments of varying angulation were attached to the implants to determine the ability to screw retain a restoration with either a straight or an angled screw-channel abutment.

One hundred fifty-two (76%) sites required an angled screw-channel abutment to enable screw retention. Forty-eight (24%) sites allowed screwn the anterior maxilla. The required angular correction to a screw-retained restoration was ≤15 degrees. Screw-retained restorations were frequently achievable (76%) with the use of angled screw-channel abutments or with straight abutments (24%), and lateral incisors presented a greater need for angled screw-channel abutments.

Scientific data analyzing the clinical outcomes and costs of complete dentures fabricated by using conventional and computer-aided design and computer-aided manufacturing (CAD-CAM) processes are lacking.

The purpose of this retrospective study was to compare the treatment duration, financial costs, and postdelivery adjustments of CAD-CAM and conventional removable complete dentures.

Thirty-two edentulous participants (16 women, 16 men; age 35-85 years) who had received either CAD-CAM (n=16) or conventional (n=16) maxillary and mandibular removable complete dentures provided by prosthodontists with a minimum of 2 years of experience were evaluated. The CAD-CAM denture systems were either DDS-AV (AvaDent Digital Dental Solutions) (n=11) or DD-IV (Wieland Digital Denture) (n=5). The total treatment period (days) was recorded at 3 different time points (T0 preliminary alginate impression; T1 denture delivery; T2 last scheduled postdelivery adjustment). Adjustments during the follow-up (after T2) were noted ]) nor the interaction group (conventional/CAD-CAM and DDS-AV/DD-IV)/period (P=.084/P=.171) showed any significant differences.

CAD-CAM removable complete dentures can be considered a viable alternative to conventional removable complete dentures regarding treatment duration, clinical and follow-up visits, adjustments, and maintenance requirements.

CAD-CAM removable complete dentures can be considered a viable alternative to conventional removable complete dentures regarding treatment duration, clinical and follow-up visits, adjustments, and maintenance requirements.

The selective laser melting (SLM) process has become popular for the fabrication of frameworks for metal-ceramic restorations, although their surface roughness is greater than with cast or milled frameworks. Limited information is available regarding the surface mechanical characteristics of cobalt-chromium (Co-Cr) SLM-manufactured restorations.

The purpose of this invitro study was to adapt the laser parameters for a remelting strategy, scanning the outer boundary of Co-Cr specimens, to reduce surface roughness and solidification defects, to determine microhardness, to investigate surface morphology and microstructure, and to establish surface mechanical characteristics.

Co-Cr specimens were SLM manufactured by using a typical melting (TM) strategy and an adaptive remelting (AR) strategy. The AR strategy involves rescanning 50% of the contour, varying the laser parameters. The roughness parameters considered were Ra and Rz. Vickers hardness was measured by microindentation with a 9.81-N force (ASTM E384-17).