OBJECTIVE The objective was to describe the experience of patients in self-managing. METHOD Phenomenology design was used in this study. Fifhteen of families who have family member which undergoing hemodialysis were recruited as participants. In-depth interviews were conducted at April to July 2018 to explore of the experiences of family in patients’ self-managing. Data were analyzed using Colaizzi. RESULT We found four themes of patients’self-management which reported by their family. There themes were (1) having positive and negative views on life changes after undergoing hemodialysis, (2) spirit for undergoing the process of hemodialysis, (3) controlling the activity and (4) limitation of food while undergoing hemodialysis and patient’s expectations during hemodialysis. CONCLUSION Self-management of patients who receive hemodialysis includes self-management in physical form (controlling activities and food restrictions) and psychological (views on life changes and life zest). OBJECTIVE This study aimed to systematically examine the factors associated with family resilience to minimize the risk of post-traumatic stress disorder (PTSD) due to disasters. METHOD Systematic reviews were carried out using the PRISMA model. The articles were collected from 5 database sources including Proquest, MEDLINE, CINAHL, Science Direct, and Springer Link. The keywords used are family resilience, post-traumatic stress disorder, and disaster. Inclusion criteria include English language, quantitative study, articles published from 2014 to 2018. The author found review of 823 articles, finally selected 11 articles that meet the inclusion criteria. RESULTS Family resilience was affected by conflict (18.1%), communication (9%), family support (54.5%), and improvement in resilience programs (27.2%). CONCLUSION Psychosocial support in the family after the family experiencing a disaster needs to be carried out continuously and scheduled. VX803 Antimony trisulfide (Sb2S3) is industrially important for processes ranging from a semiconductor dopant through batteries to a flame retardant. Approaches for fabricating Sb2S3 nanostructures or thin films are by chemical or physicochemical methods, while there have been no report focused on the biological synthesis of nano Sb2S3. In the present study, we fabricated nano-broccoli-like Sb2S3 using Sb(V) reducing bacteria. Thirty four marine and terrestrial strains are capable of fabricating Sb2S3 after 1-5 days of incubation in different selective media. The nano-broccoli-like bio-Sb2S3 was light sensitive between 400-550 nm, acting as a photo-catalyst with the bandgap energy of 1.84 eV. Moreover, kinetic and mechanism studies demonstrated that a k value of ∼0.27 h-1 with an R2 = 0.99. The bio-Sb2S3 supplemented system exhibited approximately 18.4 times higher photocatalytic activity for degrading methyl orange (MO) to SO42-, CO2 and H2O compared with that of control system, which had a k value of ∼0.015 h-1 (R2 = 0.99) under visible light. Bacterial community shift analyses showed that the addition of S or Fe species to the media significantly changed the bacterial communities driven by antimony stress. From this work it appears Clostridia, Bacilli and Gammaproteobacteria from marine sediment are potentially ideal candidates for fabricating bio-Sb2S3 due to their excellent electron transfer capability. Based on the above results, we propose a potential visible light bacterially catalyzed self-purification of both heavy metal and persistent organic contamination polluted coastal waters. d-Psicose, as important rare sugar and epimer of d-fructose on the C-3 position, displays unique health benefits and physiological functions in various fields. The production of d-psicose is currently obtained via enzymatic bioconversion, mostly with of d-tagatose 3-epimerase. In the present study, the isomerization of d-fructose into d-psicose was achieved by constructing engineered food-grade Bacillus subtilis through fermentation. After optimizing the fermentation conditions of the recombinant strain, the yield of d-psicose reached up to 4.56 g/L, representing an over 8-fold increase in the yield compared to unoptimized conditions, with a d-fructose conversion rate of 56.26 % when the strain was cultured at 35 ℃ for 24 h with 5 g/L d-fructose and 5 mM of Mn2+. In addition, 30 g of wasted apple hydrolysate were fermented by engineered B. subtilis and gained 7.76 g/L of d-psicose at a conversion rate of 25.86 % (w/w). L-glutamate oxidase (LGOX) catalyzes the oxidative deamination of l-glutamate to α-ketoglutarate (α-KG) with the formation of ammonia and hydrogen peroxide. Consequently, identifying a novel LGOX with high enzymatic activity is a prime target for industrial biotechnology. In this study, error-prone PCR mutagenesis of Streptomyces mobaraensis LGOX followed by high-throughput screening was performed to yield four single point mutants with improved enzymatic activity, termed F94L, S280T, I282M and H533R. Moreover, site-saturation mutagenesis at these four residues was employed, yielding two additionally improved mutants, termed I282L and H533L. Subsequently, we employed combinatorial mutagenesis of two, three and four point mutants, and the best mutant S280TH533L showed 90 % higher enzymatic activity than the wild-type control. The data also showed that the presence of these point mutations greatly enhanced enzymatic activity, but did not alter its optimum temperature and pH. Furthermore, the S280TH533L mutant had the maximal velocity (Vmax) of 231.3 μmol/mg/min and the Michaelis-Menten constant (KM) of 2.7 mM, which were the highest Vmax and lowest KM values of LGOX reported so far. Finally, we developed a whole-cell biocatalyst for α-KG production by co-expression of both S280TH533L mutant and KatE catalase. Randomized ribosome binding site (RBS) sequences were introduced to generate vectors with varying expression levels of S280TH533L and KatE, and two optimized co-expression strains were obtained after screening. The α-KG production reached a maximum titer of 181.9 g/L after 12 h conversation using the optimized whole-cell biocatalyst, with a molar conversion rate of substrate higher than 86.3 % in the absence of exogenous catalase, while the molar conversion rate of substrate using the wild-type biocatalyst was less than 30 %. Taken together, these data suggest that the engineering of LGOX has great potentials to enhance the industrial production of α-KG.