Proton-pump inhibitors (PPIs) are one of the most prescribed drugs. Their dermatological adverse reactions are multiple and vary in severity.

This review discusses all reported cutaneous side effects of PPIs in order to help physicians understand them and provide appropriate management.

A thorough search of PubMed, Embase, and FDAAQ8 drugs websites was conducted. 56 articles including case reports, case series, and review articles of PPI-induced cutaneous adverse reactions were selected. Data were recorded regarding patient age, gender, history, clinical manifestations, diagnostic tests, management, and clinical outcomes.

PPI-induced adverse skin reactions are mostly immunological and include both immediate and delayed-type hypersensitivity reactions. These reactions are sometimes life-threatening. All PPIs can induce immediate IgE-mediated reactions. Most of previously published cases of delayed-type hypersensitivity reactions have involved esomeprazole, omeprazole, and lansoprazole. Skin tests are helpful in confirming PPI-induced hypersensitivity reactions and diagnosing potential cross-reactivities. PPIs should also be added to our list of usual suspects when considering possible culprits for a new presentation of drug-induced subacute lupus erythematosus. PPI-related occupational contact dermatitis has also been numerously reported.

PPIs should be considered in our list of culprits when considering a patient with a cutaneous drug reaction, taking into account that these drugs can cause severe immunological manifestations.

PPIs should be considered in our list of culprits when considering a patient with a cutaneous drug reaction, taking into account that these drugs can cause severe immunological manifestations.

To use tissue engineering muscle repair (TEMR) for regenerating the lingual musculature of hemiglossectomized rats using neonatal myoblasts (NM) on porcine acellular urinary bladder matrix (AUBM).

The study used 80 male rats. A volumetric muscle loss (VML) injury was created on the left side of the tongue. The rats were randomized into four groups Group 1 (AUBM+myoblasts); Group 2 (AUBM); Group 3 (myoblasts); and Group 4 (control). NM were obtained from neonatal rats. The animals were weighed on day 0 and just before euthanasia. Five rats in each group were euthanized at days 2, 14, 28, and 42; the tongues were prepared for morphometric analysis, postoperative left hemitongue weight, and immunohistochemical analysis (desmin, CD-31, and anti-neurofilament).

The weight gain from greatest to least was as follows AUBM+myoblasts>myoblasts>AUBM>control. The tongue dorsum occupied by VML, and difference in mg between control side and intervened side from least to great was as follows AUBM+myoblasts<myoblasts<AUBM<control. The order from highest to lowest antibody positivity was as follows AUBM+myoblasts>myoblasts>AUBM>control.

The use of porcine AUBM and NM for the regeneration of lingual musculature was found to be an effective TEMR treatment for repairing tongue VML injury.

The use of porcine AUBM and NM for the regeneration of lingual musculature was found to be an effective TEMR treatment for repairing tongue VML injury.Etiology and therapeutic targets of diabetic nephropathy.

To explore the experience of parenting for younger stroke survivors (aged 18 to 64years at the time of the stroke).

Stroke among younger adults increased 43% between 2000 and 2010. The social, emotional and physical functioning of younger adults affects multiple aspects of their lives including parenting. GSK3368715 concentration There is limited research on the experience of parenting after stroke.

This is a qualitative descriptive study.

We conducted individual semi-structured interviews with 10 younger adults who were actively parenting children under the age of 18years at the time of stroke. Conventional content analysis was used to analyse the data. We report the methods and results using the COREQ checklist.

Impairments from stroke disrupted participants’ identity, relationships and roles as a parent. The degree to which parenting abilities and behaviours were affected by stroke was contingent upon the type and severity of impairments as well as the children’s age. Participants also observed emotional and behavioural changes in their children in response to their stroke. Support from family, friends, healthcare providers and children’s school/day care was crucial to participants throughout their stroke recovery. Two major themes emerged (a) finding a new normal; and (b) support for parenting post-stroke.

Findings enable a deeper understanding of the distinct parenting challenges younger stroke survivors face and can inform future research on this population.

Study findings highlight the need for continual and tailored follow-up by nurses and other allied healthcare professionals to decrease the difficulty stroke survivors experience when trying to resume their role as parents.

Study findings highlight the need for continual and tailored follow-up by nurses and other allied healthcare professionals to decrease the difficulty stroke survivors experience when trying to resume their role as parents.WHAT IS KNOWN ON THE SUBJECT? Since the first decade of this century, few qualitative studies and literature reviews have reported consumers’ experiences of psychosis and recovery. The findings from these studies need further exploration. WHAT DOES THE PAPER ADD TO EXISTING KNOWLEDGE? New insights into consumers’ experiences of psychosis were generated. Additionally, understanding of consumers’ conceptions and experiences of recovery were reported. Consumers’ insights into the enablers and barriers to recovery that they encountered were also identified. Gaps in the literature remain, particularly those related to the effects of gender and culture on consumers’ experiences of and recovery from psychosis. WHAT ARE THE IMPLICATIONS FOR PRACTICE? Nurses’ understanding of consumers’ perspectives and experiences of psychosis is vital to enhancing the quality of mental health nursing when caring for people living with psychosis. To support user-based recovery, mental health nurses need to incorporate person-centred approaches and reduce their preferencing of medical understandings of recovery.